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Kinetic Deuterium Isotope Effects in Cytochrome P450 Oxidation Reactions
Cytochrome P450 (P450) enzymes account for ~ 75% of the metabolism of drugs. Most of the reactions catalyzed by P450s are mixed-function oxidations, and a C-H bond is (usually) broken. The rate-limiting nature of this step can be analyzed using the kinetic isotope effect (KIE) approach. The most rel...
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| Publicado no: | J Labelled Comp Radiopharm |
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| Autor principal: | |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4861049/ https://ncbi.nlm.nih.gov/pubmed/24285515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jlcr.3031 |
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