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Kinetic Isotope Effects in Hydroxylation Reactions Effected by Cytochrome P450 Compounds I Implicate Multiple Electrophilic Oxidants for P450-Catalyzed Oxidations

Kinetic isotope effects were measured for oxidations of (S,S)-2-(p-trifluoromethylphenyl)cyclopropylmethane containing zero, two, and three deuterium atoms on the methyl group by Compounds I from the cytochrome P450 enzymes CYP119 and CYP2B4 at 22 °C. The oxidations displayed saturation kinetics, wh...

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Main Authors: Sheng, Xin, Zhang, Haoming, Hollenberg, Paul F., Newcomb, Martin
Format: Artigo
Jezik:Inglês
Izdano: 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2664160/
https://ncbi.nlm.nih.gov/pubmed/19182902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi802279d
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