eIF2 interactions with initiator tRNA and eIF2B are regulated by post-translational modifications and conformational dynamics

Translation of messenger RNA (mRNA) into proteins is key to eukaryotic gene expression and begins when initiation factor-2 (eIF2) delivers methionyl initiator tRNA (Met-tRNA(i) (Met)) to ribosomes. This first step is controlled by eIF2B mediating guanine nucleotide exchange on eIF2. We isolated eIF2...

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Detalhes bibliográficos
Publicado no:Cell Discov
Main Authors: Beilsten-Edmands, Victoria, Gordiyenko, Yuliya, Kung, Jocky CK, Mohammed, Shabaz, Schmidt, Carla, Robinson, Carol V
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860841/
https://ncbi.nlm.nih.gov/pubmed/27462419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2015.20
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