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Structural basis for the inhibition of translation through eIF2α phosphorylation
One of the responses to stress by eukaryotic cells is the down-regulation of protein synthesis by phosphorylation of translation initiation factor eIF2. Phosphorylation results in low availability of the eIF2 ternary complex (eIF2-GTP-tRNAi) by affecting the interaction of eIF2 with its GTP-GDP exch...
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| I publikationen: | Nat Commun |
|---|---|
| Huvudupphovsmän: | , , |
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
Nature Publishing Group UK
2019
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6572841/ https://ncbi.nlm.nih.gov/pubmed/31201334 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10606-1 |
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