Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular-fibrosis and tumor progression

Fibrosis compromises pancreatic ductal carcinoma (PDAC) treatment and contributes to patient mortality yet anti-stromal therapies are controversial. We found that human PDACs with impaired epithelial transforming growth factor β (TGF-β) signaling have elevated epithelial Stat3 activity and develop a...

Full description

Saved in:
Bibliographic Details
Published in:Nat Med
Main Authors: Laklai, Hanane, Miroshnikova, Yekaterina A., Pickup, Michael W., Collisson, Eric A., Kim, Grace E., Barrett, Alex S., Hill, Ryan C., Lakins, Johnathon N., Schlaepfer, David D., Mouw, Janna K., LeBleu, Valerie S., Roy, Nilotpal, Novitskiy, Sergey V., Johansen, Julia S., Poli, Valeria, Kalluri, Raghu, Iacobuzio-Donahue, Christine A., Wood, Laura D., Hebrok, Matthias, Hansen, Kirk, Moses, Harold L., Weaver, Valerie M.
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860133/
https://ncbi.nlm.nih.gov/pubmed/27089513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4082
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items