Airway epithelial DUOX1 mediates allergen-induced IL-33 secretion and activation of type 2 immune responses

BACKGROUND: The interleukin (IL)-1 family member IL-33 plays a critical role in type-2 innate immune responses to allergens, and is an important mediator of allergic asthma. The mechanisms by which allergens provoke epithelial IL-33 secretion are still poorly understood. OBJECTIVE: Based on previous...

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Publicado no:J Allergy Clin Immunol
Main Authors: Hristova, Milena, Habibovic, Aida, Veith, Carmen, Janssen-Heininger, Yvonne M.W., Dixon, Anne E., Geiszt, Miklos, van der Vliet, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860024/
https://ncbi.nlm.nih.gov/pubmed/26597162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.10.003
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