Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema

Aging is associated with a gradual loss of lung function due to increased cellular senescence, decreased regenerative capacity, and impaired innate host defense. One important aspect of innate airway epithelial host defense to nonmicrobial triggers is the secretion of alarmins such as IL-33 and acti...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Schiffers, Caspar, Lundblad, Lennart K. A., Hristova, Milena, Habibovic, Aida, Dustin, Christopher M., Daphtary, Nirav, Aliyeva, Minara, Seward, David J., Janssen-Heininger, Yvonne M. W., Wouters, Emiel F. M., Reynaert, Niki L., van der Vliet, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321859/
https://ncbi.nlm.nih.gov/pubmed/33951398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00021.2021
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