Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema

Aging is associated with a gradual loss of lung function due to increased cellular senescence, decreased regenerative capacity, and impaired innate host defense. One important aspect of innate airway epithelial host defense to nonmicrobial triggers is the secretion of alarmins such as IL-33 and acti...

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Pubblicato in:Am J Physiol Lung Cell Mol Physiol
Autori principali: Schiffers, Caspar, Lundblad, Lennart K. A., Hristova, Milena, Habibovic, Aida, Dustin, Christopher M., Daphtary, Nirav, Aliyeva, Minara, Seward, David J., Janssen-Heininger, Yvonne M. W., Wouters, Emiel F. M., Reynaert, Niki L., van der Vliet, Albert
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2021
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321859/
https://ncbi.nlm.nih.gov/pubmed/33951398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00021.2021
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