Downregulation of DUOX1 function contributes to aging-related impairment of innate airway injury responses and accelerated senile emphysema

Aging is associated with a gradual loss of lung function due to increased cellular senescence, decreased regenerative capacity, and impaired innate host defense. One important aspect of innate airway epithelial host defense to nonmicrobial triggers is the secretion of alarmins such as IL-33 and acti...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Physiol Lung Cell Mol Physiol
Prif Awduron: Schiffers, Caspar, Lundblad, Lennart K. A., Hristova, Milena, Habibovic, Aida, Dustin, Christopher M., Daphtary, Nirav, Aliyeva, Minara, Seward, David J., Janssen-Heininger, Yvonne M. W., Wouters, Emiel F. M., Reynaert, Niki L., van der Vliet, Albert
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2021
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8321859/
https://ncbi.nlm.nih.gov/pubmed/33951398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00021.2021
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