DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma

Chronic inflammation with mucous metaplasia and airway remodeling are hallmarks of allergic asthma, and these outcomes have been associated with enhanced expression and activation of EGFR signaling. Here, we demonstrate enhanced expression of EGFR ligands such as amphiregulin as well as constitutive...

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Vydáno v:JCI Insight
Hlavní autoři: Habibovic, Aida, Hristova, Milena, Heppner, David E., Danyal, Karamatullah, Ather, Jennifer L., Janssen-Heininger, Yvonne M.W., Irvin, Charles G., Poynter, Matthew E., Lundblad, Lennart K., Dixon, Anne E., Geiszt, Miklos, van der Vliet, Albert
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085603/
https://ncbi.nlm.nih.gov/pubmed/27812543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88811
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