DUOX1 mediates persistent epithelial EGFR activation, mucous cell metaplasia, and airway remodeling during allergic asthma

Chronic inflammation with mucous metaplasia and airway remodeling are hallmarks of allergic asthma, and these outcomes have been associated with enhanced expression and activation of EGFR signaling. Here, we demonstrate enhanced expression of EGFR ligands such as amphiregulin as well as constitutive...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Habibovic, Aida, Hristova, Milena, Heppner, David E., Danyal, Karamatullah, Ather, Jennifer L., Janssen-Heininger, Yvonne M.W., Irvin, Charles G., Poynter, Matthew E., Lundblad, Lennart K., Dixon, Anne E., Geiszt, Miklos, van der Vliet, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085603/
https://ncbi.nlm.nih.gov/pubmed/27812543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.88811
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