Acrolein and thiol-reactive electrophiles suppress allergen-induced innate airway epithelial responses by inhibition of DUOX1 and EGFR

Acrolein is a major thiol-reactive component of cigarette smoke (CS) that is thought to contribute to increased asthma incidence associated with smoking. Here, we explored the effects of acute acrolein exposure on innate airway responses to two common airborne allergens, house dust mite and Alternar...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: Danyal, Karamatullah, de Jong, Willem, O'Brien, Edmund, Bauer, Robert A., Heppner, David E., Little, Andrew C., Hristova, Milena, Habibovic, Aida, van der Vliet, Albert
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2016
Assuntos:
Aritcles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5130541/
https://ncbi.nlm.nih.gov/pubmed/27612966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00276.2016
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