Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

Tau toxicity has been implicated in the emergence of synaptic dysfunction in Alzheimer’s disease (AD), but the mechanism by which tau alters synapse physiology and leads to cognitive decline is unclear. Here, we report abnormal acetylation of K274 and K281 on tau, identified in AD brains, promotes m...

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Veröffentlicht in:Neuron
Hauptverfasser: Tracy, Tara E., Sohn, Peter Dongmin, Minami, S. Sakura, Wang, Chao, Min, Sang-Won, Li, Yaqiao, Zhou, Yungui, Le, David, Lo, Iris, Ponnusamy, Ravikumar, Cong, Xin, Schilling, Birgit, Ellerby, Lisa M., Huganir, Richard L., Gan, Li
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859346/
https://ncbi.nlm.nih.gov/pubmed/27041503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.03.005
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