Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss

Tau toxicity has been implicated in the emergence of synaptic dysfunction in Alzheimer’s disease (AD), but the mechanism by which tau alters synapse physiology and leads to cognitive decline is unclear. Here, we report abnormal acetylation of K274 and K281 on tau, identified in AD brains, promotes m...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Neuron
Egile Nagusiak: Tracy, Tara E., Sohn, Peter Dongmin, Minami, S. Sakura, Wang, Chao, Min, Sang-Won, Li, Yaqiao, Zhou, Yungui, Le, David, Lo, Iris, Ponnusamy, Ravikumar, Cong, Xin, Schilling, Birgit, Ellerby, Lisa M., Huganir, Richard L., Gan, Li
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859346/
https://ncbi.nlm.nih.gov/pubmed/27041503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2016.03.005
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