The NAE inhibitor pevonedistat interacts with the HDAC inhibitor belinostat to target AML cells by disrupting the DDR

Two classes of novel agents, NEDD8-activating enzyme (NAE) and histone deacetylase (HDAC) inhibitors, have shown single-agent activity in acute myelogenous leukemia (AML)/myelodysplastic syndrome (MDS). Here we examined mechanisms underlying interactions between the NAE inhibitor pevonedistat (MLN49...

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Veröffentlicht in:Blood
Hauptverfasser: Zhou, Liang, Chen, Shuang, Zhang, Yu, Kmieciak, Maciej, Leng, Yun, Li, Lihong, Lin, Hui, Rizzo, Kathryn A., Dumur, Catherine I., Ferreira-Gonzalez, Andrea, Rahmani, Mohamed, Povirk, Lawrence, Chalasani, Sri, Berger, Allison J., Dai, Yun, Grant, Steven
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2016
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4859196/
https://ncbi.nlm.nih.gov/pubmed/26851293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-06-653717
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