A regimen combining the Wee1 inhibitor AZD1775 with HDAC inhibitors targets human acute myeloid leukemia cells harboring various genetic mutations

AZD1775 targets the cell cycle checkpoint kinase Wee1 and potentiates genotoxic agent cytotoxicity through p53-dependent or -independent mechanisms. Here, we report that AZD1775 interacted synergistically with histone deacetylase inhibitors (HDACIs e.g., Vorinostat), which interrupt the DNA damage r...

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Bibliografske podrobnosti
izdano v:Leukemia
Main Authors: Zhou, Liang, Zhang, Yu, Chen, Shuang, Kmieciak, Maciej, Leng, Yun, Lin, Hui, Rizzo, Kathryn A., Dumur, Catherine I., Ferreira-Gonzalez, Andrea, Dai, Yun, Grant, Steven
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387110/
https://ncbi.nlm.nih.gov/pubmed/25283841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.296
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