A regimen combining the Wee1 inhibitor AZD1775 with HDAC inhibitors targets human acute myeloid leukemia cells harboring various genetic mutations

AZD1775 targets the cell cycle checkpoint kinase Wee1 and potentiates genotoxic agent cytotoxicity through p53-dependent or -independent mechanisms. Here, we report that AZD1775 interacted synergistically with histone deacetylase inhibitors (HDACIs e.g., Vorinostat), which interrupt the DNA damage r...

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Publicado en:Leukemia
Main Authors: Zhou, Liang, Zhang, Yu, Chen, Shuang, Kmieciak, Maciej, Leng, Yun, Lin, Hui, Rizzo, Kathryn A., Dumur, Catherine I., Ferreira-Gonzalez, Andrea, Dai, Yun, Grant, Steven
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387110/
https://ncbi.nlm.nih.gov/pubmed/25283841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2014.296
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