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Activation of the E3 Ubiquitin Ligase Parkin
The PINK1/Parkin-dependent mitochondrial quality control pathway mediates the clearance of damaged organelles, but appears to be disrupted in Parkinson’s disease. Upon mitochondrial stress, PINK1 activates the E3 Ubiquitin (Ub) ligase Parkin through phosphorylation of the Ub-like (UBL) domain of Par...
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| Publicado no: | Biochem Soc Trans |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4859148/ https://ncbi.nlm.nih.gov/pubmed/25849928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST20140321 |
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