UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts

During transcription, most eukaryotic genes generate multiple alternative cleavage and polyadenylation (APA) sites, leading to the production of transcript isoforms with variable lengths in the 3’ untranslated region (3’UTR). In contrast to somatic cells, male germ cells, especially pachytene sperma...

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Udgivet i:PLoS Genet
Main Authors: Bao, Jianqiang, Vitting-Seerup, Kristoffer, Waage, Johannes, Tang, Chong, Ge, Ying, Porse, Bo T., Yan, Wei
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858225/
https://ncbi.nlm.nih.gov/pubmed/27149259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005863
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