UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts

During transcription, most eukaryotic genes generate multiple alternative cleavage and polyadenylation (APA) sites, leading to the production of transcript isoforms with variable lengths in the 3’ untranslated region (3’UTR). In contrast to somatic cells, male germ cells, especially pachytene sperma...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Genet
Prif Awduron: Bao, Jianqiang, Vitting-Seerup, Kristoffer, Waage, Johannes, Tang, Chong, Ge, Ying, Porse, Bo T., Yan, Wei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2016
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858225/
https://ncbi.nlm.nih.gov/pubmed/27149259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005863
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