UPF2-Dependent Nonsense-Mediated mRNA Decay Pathway Is Essential for Spermatogenesis by Selectively Eliminating Longer 3'UTR Transcripts

During transcription, most eukaryotic genes generate multiple alternative cleavage and polyadenylation (APA) sites, leading to the production of transcript isoforms with variable lengths in the 3’ untranslated region (3’UTR). In contrast to somatic cells, male germ cells, especially pachytene sperma...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Bao, Jianqiang, Vitting-Seerup, Kristoffer, Waage, Johannes, Tang, Chong, Ge, Ying, Porse, Bo T., Yan, Wei
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4858225/
https://ncbi.nlm.nih.gov/pubmed/27149259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005863
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