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Design, synthesis, and kinetic analysis of potent protein N-terminal methyltransferase 1 inhibitors()
The protein N-terminal methyltransferase 1 (NTMT1) methylates the α-N-terminal amines of proteins. NTMT1 is upregulated in a variety of cancers and knockdown of NTMT1 results in cell mitotic defects. Therefore, NTMT1 inhibitors could be potential anticancer therapeutics. This study describes the des...
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| Publicado no: | Org Biomol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4857722/ https://ncbi.nlm.nih.gov/pubmed/25712161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5ob00120j |
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