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Discovery of Bisubstrate Inhibitors for Protein N‑Terminal Methyltransferase 1
Protein N-terminal methyltransferase 1 (NTMT1) plays an important role in regulating mitosis and DNA repair. Here, we describe the discovery of a potent NTMT1 bisubstrate inhibitor 4 (IC(50) = 35 ± 2 nM) that exhibits greater than 100-fold selectivity against a panel of methyltransferases. We also r...
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| Udgivet i: | J Med Chem |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6760264/ https://ncbi.nlm.nih.gov/pubmed/30883119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00206 |
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