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Chemoproteomic study uncovers HemK2/KMT9 as a new target for NTMT1 bisubstrate inhibitors

Understanding the selectivity of methyltransferase inhibitors is important to dissect the functions of each methyltransferase target. From this perspective, here we report a chemoproteomic study to profile the selectivity of a potent protein N-terminal methyltransferase 1 (NTMT1) bisubstrate inhibit...

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Chen, Dongxing, Meng, Ying, Yu, Dan, Noinaj, Nicholas, Cheng, Xiaodong, Huang, Rong
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8286339/
https://ncbi.nlm.nih.gov/pubmed/34192867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.1c00279
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