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Facile synthesis of SAM–peptide conjugates through alkyl linkers targeting protein N-terminal methyltransferase 1()

We report the first chemical synthesis of SAM–peptide conjugates through alkyl linkers to prepare bisubstrate analogs for protein methyltransferases. We demonstrate its application by developing a series of bisubstrate inhibitors for protein N-terminal methyltransferase 1 and the most potent one exh...

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Detalhes bibliográficos
Publicado no:RSC Adv
Main Authors: Zhang, Gang, Huang, Rong
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5004777/
https://ncbi.nlm.nih.gov/pubmed/27588169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C5RA20625A
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