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A facile N-mercaptoethoxyglycinamide (MEGA) linker approach to peptide thioesterification and cyclization
The C-terminal selective electrophilic activation of polypeptides is essential for site-specific peptide modification and conjugation techniques such as Native Chemical Ligation (NCL). Peptide C-terminal α-thioesters are particularly valuable precursors for NCL, due to their hydrolytic stability in...
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| Foilsithe in: | J Am Chem Soc |
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| Main Authors: | , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2017
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5731643/ https://ncbi.nlm.nih.gov/pubmed/28230996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b13271 |
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