Hsp90 protein interacts with phosphorothioate oligonucleotides containing hydrophobic 2′-modifications and enhances antisense activity

RNase H1-dependent antisense oligonucleotides (ASOs) are chemically modified to enhance pharmacological properties. Major modifications include phosphorothioate (PS) backbone and different 2′-modifications in 2–5 nucleotides at each end (wing) of an ASO. Chemical modifications can affect protein bin...

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Bibliographische Detailangaben
Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Liang, Xue-Hai, Shen, Wen, Sun, Hong, Kinberger, Garth A., Prakash, Thazha P., Nichols, Joshua G., Crooke, Stanley T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2016
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856991/
https://ncbi.nlm.nih.gov/pubmed/26945041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw144
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