Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer.

Regional increases in DNA methylation occur in normally unmethylated cytosine-rich areas in neoplastic cells. These changes could potentially alter chromatin structure to inactivate gene transcription or generate DNA instability. We now show that, in human lung and colon cancer DNA, hypermethylation...

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Main Authors: Makos, M, Nelkin, B D, Lerman, M I, Latif, F, Zbar, B, Baylin, S B
Format: Artigo
Jezik:Inglês
Izdano: 1992
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC48567/
https://ncbi.nlm.nih.gov/pubmed/1347428
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