The short arm of chromosome 11 is a "hot spot" for hypermethylation in human neoplasia.

Inactivation of normally expressed genes may play a role in the formation and/or progression of human cancers. Methylation of cytosine in DNA could potentially participate in such alterations of gene expression. Abnormalities in DNA methylation are a consistent feature of human neoplasms, and we now...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: de Bustros, A, Nelkin, B D, Silverman, A, Ehrlich, G, Poiesz, B, Baylin, S B
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1988
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC281826/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2840671/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.15.5693
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