Distinct hypermethylation patterns occur at altered chromosome loci in human lung and colon cancer.

Regional increases in DNA methylation occur in normally unmethylated cytosine-rich areas in neoplastic cells. These changes could potentially alter chromatin structure to inactivate gene transcription or generate DNA instability. We now show that, in human lung and colon cancer DNA, hypermethylation...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Makos, M, Nelkin, B D, Lerman, M I, Latif, F, Zbar, B, Baylin, S B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC48567/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1347428/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.5.1929
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