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Structural Basis for Substrate Selectivity of the E3 Ligase COP1
COP1 proteins are E3 ubiquitin ligases that regulate phototropism in plants and target transcription factors for degradation in mammals. The substrate-binding region of COP1 resides within a WD40-repeat domain that also binds to Trib proteins, which are adaptors for C/EBPα degradation. We report her...
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| Veröffentlicht in: | Structure |
|---|---|
| Hauptverfasser: | , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4856590/ https://ncbi.nlm.nih.gov/pubmed/27041596 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.03.002 |
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