Structural Basis for Substrate Selectivity of the E3 Ligase COP1

COP1 proteins are E3 ubiquitin ligases that regulate phototropism in plants and target transcription factors for degradation in mammals. The substrate-binding region of COP1 resides within a WD40-repeat domain that also binds to Trib proteins, which are adaptors for C/EBPα degradation. We report her...

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Detalhes bibliográficos
Publicado no:Structure
Main Authors: Uljon, Sacha, Xu, Xiang, Durzynska, Izabela, Stein, Sarah, Adelmant, Guillaume, Marto, Jarrod A., Pear, Warren S., Blacklow, Stephen C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856590/
https://ncbi.nlm.nih.gov/pubmed/27041596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2016.03.002
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