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Single-molecule imaging reveals a collapsed conformational state for DNA-bound cohesin

Cohesin is essential for the hierarchical organization of the eukaryotic genome and plays key roles in many aspects of chromosome biology. The conformation of cohesin bound to DNA remains poorly defined, leaving crucial gaps in our understanding of how cohesin fulfills its biological functions. Here...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Stigler, Johannes, Çamdere, Gamze Ö., Koshland, Douglas E., Greene, Eric C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856582/
https://ncbi.nlm.nih.gov/pubmed/27117417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.04.003
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