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I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs

During the 1950s, sheep ranchers in the western United States experienced episodic outbreaks of cyclopic lambs. In this highlight I describe how these mysterious incidents were traced to the grazing of Veratrum californicum wildflowers by pregnant ewes, leading to the discovery of cyclopamine (1) as...

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Detalhes bibliográficos
Publicado no:Nat Prod Rep
Autor principal: Chen, James K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856577/
https://ncbi.nlm.nih.gov/pubmed/26787175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5np00153f
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