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I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs
During the 1950s, sheep ranchers in the western United States experienced episodic outbreaks of cyclopic lambs. In this highlight I describe how these mysterious incidents were traced to the grazing of Veratrum californicum wildflowers by pregnant ewes, leading to the discovery of cyclopamine (1) as...
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Publicado no: | Nat Prod Rep |
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Autor principal: | |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4856577/ https://ncbi.nlm.nih.gov/pubmed/26787175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5np00153f |
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