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Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer
A promising agent for use in prostate cancer therapy is the Hedgehog (Hh) signaling pathway inhibitor, cyclopamine. This compound, however, has the potential for causing serious side effects in non-tumor tissues. To minimize these bystander toxicities, we have designed and synthesized two novel pept...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2666345/ https://ncbi.nlm.nih.gov/pubmed/18249125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.01.012 |
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