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Hedgehog pathway as a drug target: Smoothened inhibitors in development
Emerging laboratory and clinical investigations demonstrate that Hedgehog signaling (Hh) represents a novel therapeutic target in various human cancers. This conserved signaling pathway precisely regulates self-renewal and terminal differentiation in embryonic development, but is typically silenced...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Dove Medical Press
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3325001/ https://ncbi.nlm.nih.gov/pubmed/22500124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S21957 |
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