Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions

The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct, remain uncertain. Using mouse models of paralog deficiency, we demonstrate that they are not eq...

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Vydáno v:eLife
Hlavní autoři: Villarino, Alejandro, Laurence, Arian, Robinson, Gertraud W, Bonelli, Michael, Dema, Barbara, Afzali, Behdad, Shih, Han-Yu, Sun, Hong-Wei, Brooks, Stephen R, Hennighausen, Lothar, Kanno, Yuka, O'Shea, John J
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2016
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4856466/
https://ncbi.nlm.nih.gov/pubmed/26999798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08384
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