Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis

Both the WNT/β-catenin and hedgehog signaling pathways are important in the regulation of limb development, chondrocyte differentiation, and degeneration of articular cartilage in osteoarthritis (OA). It is not clear how these signaling pathways interact in interzone cell differentiation and synovia...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Rockel, Jason S., Yu, Chunying, Whetstone, Heather, Craft, April M., Reilly, Katherine, Ma, Henry, Tsushima, Hidetoshi, Puviindran, Vijitha, Al-Jazrawe, Mushriq, Keller, Gordon M., Alman, Benjamin A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855923/
https://ncbi.nlm.nih.gov/pubmed/27018594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80205
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