Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis

Both the WNT/β-catenin and hedgehog signaling pathways are important in the regulation of limb development, chondrocyte differentiation, and degeneration of articular cartilage in osteoarthritis (OA). It is not clear how these signaling pathways interact in interzone cell differentiation and synovia...

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發表在:J Clin Invest
Main Authors: Rockel, Jason S., Yu, Chunying, Whetstone, Heather, Craft, April M., Reilly, Katherine, Ma, Henry, Tsushima, Hidetoshi, Puviindran, Vijitha, Al-Jazrawe, Mushriq, Keller, Gordon M., Alman, Benjamin A.
格式: Artigo
語言:Inglês
出版: American Society for Clinical Investigation 2016
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855923/
https://ncbi.nlm.nih.gov/pubmed/27018594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI80205
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