Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma

Asthma is defined by airway inflammation and hyperresponsiveness, and contributes to morbidity and mortality worldwide. Although bronchodilation is a cornerstone of treatment, current bronchodilators become ineffective with worsening asthma severity. We investigated an alternative pathway that invol...

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Publicado en:Proc Natl Acad Sci U S A
Main Authors: Ghosh, Arnab, Koziol-White, Cynthia J., Asosingh, Kewal, Cheng, Georgina, Ruple, Lisa, Groneberg, Dieter, Friebe, Andreas, Comhair, Suzy A. A., Stasch, Johannes-Peter, Panettieri, Reynold A., Aronica, Mark A., Erzurum, Serpil C., Stuehr, Dennis J.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4855555/
https://ncbi.nlm.nih.gov/pubmed/27071111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524398113
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