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Nitric Oxide and Heat Shock Protein 90 Activate Soluble Guanylate Cyclase by Driving Rapid Change in Its Subunit Interactions and Heme Content

The chaperone heat shock protein 90 (hsp90) associates with signaling proteins in cells including soluble guanylate cyclase (sGC). hsp90 associates with the heme-free (apo) sGC-β1 subunit and helps to drive heme insertion during maturation of sGC to its NO-responsive active form. Here, we found that...

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Bibliografske podrobnosti
Main Authors: Ghosh, Arnab, Stasch, Johannes-Peter, Papapetropoulos, Andreas, Stuehr, Dennis J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4140884/
https://ncbi.nlm.nih.gov/pubmed/24733395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.559393
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