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GAPDH delivers heme to soluble guanylyl cyclase

Soluble guanylyl cyclase (sGC) is a key component of NO–cGMP signaling in mammals. Although heme must bind in the sGC β1 subunit (sGCβ) for sGC to function, how heme is delivered to sGCβ remains unknown. Given that GAPDH displays properties of a heme chaperone for inducible NO synthase, here we inve...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Dai, Yue, Sweeny, Elizabeth A., Schlanger, Simon, Ghosh, Arnab, Stuehr, Dennis J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294094/
https://ncbi.nlm.nih.gov/pubmed/32358060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013802
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