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GAPDH delivers heme to soluble guanylyl cyclase

Soluble guanylyl cyclase (sGC) is a key component of NO–cGMP signaling in mammals. Although heme must bind in the sGC β1 subunit (sGCβ) for sGC to function, how heme is delivered to sGCβ remains unknown. Given that GAPDH displays properties of a heme chaperone for inducible NO synthase, here we inve...

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Dettagli Bibliografici
Pubblicato in:J Biol Chem
Autori principali: Dai, Yue, Sweeny, Elizabeth A., Schlanger, Simon, Ghosh, Arnab, Stuehr, Dennis J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7294094/
https://ncbi.nlm.nih.gov/pubmed/32358060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013802
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