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GAPDH delivers heme to soluble guanylyl cyclase
Soluble guanylyl cyclase (sGC) is a key component of NO–cGMP signaling in mammals. Although heme must bind in the sGC β1 subunit (sGCβ) for sGC to function, how heme is delivered to sGCβ remains unknown. Given that GAPDH displays properties of a heme chaperone for inducible NO synthase, here we inve...
Gardado en:
| Publicado en: | J Biol Chem |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7294094/ https://ncbi.nlm.nih.gov/pubmed/32358060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.013802 |
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