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Myoglobin maturation is driven by the hsp90 chaperone machinery and by soluble guanylyl cyclase

Myoglobin (Mb) maturation involves heme incorporation as a final step. We investigated a role for heat shock protein (hsp) 90 in Mb maturation in C2C12 skeletal muscle myoblasts and cell lines. We found the following: 1) Hsp90 directly interacts preferentially with heme-free Mb both in purified form...

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Veröffentlicht in:FASEB J
Hauptverfasser: Ghosh, Arnab, Dai, Yue, Biswas, Pranjal, Stuehr, Dennis J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2019
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6704453/
https://ncbi.nlm.nih.gov/pubmed/31170354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201802793RR
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