An inherent dysfunction in soluble guanylyl cyclase is present in the airway of severe asthmatics and is associated with aberrant redox enzyme expression and compromised NO-cGMP signaling

A subset of asthmatics develop a severe form of the disease whose etiology involves airway inflammation along with inherent drivers that remain ill-defined. To address this, we studied human airway smooth muscle cells (HASMC), whose relaxation drives airway bronchodilation and whose dysfunction cont...

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Gepubliceerd in:Redox Biol
Hoofdauteurs: Ghosh, Arnab, Koziol-White, Cynthia J., Jester, William F., Erzurum, Serpil C., Asosingh, Kewal, Panettieri, Reynold A., Stuehr, Dennis J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2020
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Research Paper
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7772568/
https://ncbi.nlm.nih.gov/pubmed/33360351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2020.101832
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