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Lack of effect of ODQ does not exclude cGMP signalling via NO-sensitive guanylyl cyclase

BACKGROUND AND PURPOSE: Nitric oxide (NO) is known to activate NO-sensitive guanylyl cyclase (NO-GC) and to elicit cGMP production. However, NO has also been proposed to induce cGMP-independent effects. It is accepted practice to use specific NO-GC inhibitors, such as ODQ or NS2028, to assess cGMP-d...

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Dettagli Bibliografici
Autori principali: Lies, Barbara, Groneberg, Dieter, Gambaryan, Stepan, Friebe, Andreas
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834756/
https://ncbi.nlm.nih.gov/pubmed/23763290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12275
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