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Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C

Cantharidin is a natural toxin and an active constituent in a traditional Chinese medicine used to treat tumors. Cantharidin acts as a semi-selective inhibitor of PPP-family ser/thr protein phosphatases. Despite sharing a common catalytic mechanism and marked structural similarity with PP1C, PP2AC a...

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Publicado no:Biochem Pharmacol
Main Authors: Chattopadhyay, Debasish, Swingle, Mark R., Salter, Edward A., Wood, Eric, D’Arcy, Brandon, Zivanov, Catherine, Abney, Kevin, Musiyenko, Alla, Rusin, Scott F., Kettenbach, Arminja, Yet, Larry, Schroeder, Chad E., Golden, Jennifer E., Dunham, Wade H., Gingras, Anne-Claude, Banerjee, Surajit, Forbes, David, Wierzbicki, Andrzej, Honkanen, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4853234/
https://ncbi.nlm.nih.gov/pubmed/27002182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2016.03.011
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