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Suppression of ser/thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death

Fostriecin is a natural product purified from Sterptomyces extracts with antitumor activity sufficient to warrant human clinical trials. Unfortunately, difficulties associated with supply and stable drug formulation stalled further development. At a molecular level, fostriecin is known to act as a c...

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Detalhes bibliográficos
Main Authors: Theobald, Benjamin, Bonness, Kathy, Musiyenko, Alla, Andrews, Joel F., Urban, Gudrun, Huang, Xizhong, Dean, Nicholas M., Honkanen, Richard E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3748177/
https://ncbi.nlm.nih.gov/pubmed/23671329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-13-0032
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