Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C

Por Chattopadhyay, Debasish, Swingle, Mark R., Salter, Edward A., Wood, Eric, D’Arcy, Brandon, Zivanov, Catherine, Abney, Kevin, Musiyenko, Alla, Rusin, Scott F., Kettenbach, Arminja, Yet, Larry, Schroeder, Chad E., Golden, Jennifer E., Dunham, Wade H., Gingras, Anne-Claude, Banerjee, Surajit, Forbes, David, Wierzbicki, Andrzej, Honkanen, Richard E.
Publicado no Biochem Pharmacol (2016)

Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity

Por Li, Nan, Lee, Kevin, Xi, Yaguang, Zhu, Bing, Gary, Bernard D., Ramírez-Alcántara, Verónica, Gurpinar, Evrim, Canzoneri, Joshua C., Fajardo, Alexandra, Sigler, Sara, Piazza, John T., Chen, Xi, Andrews, Joel, Thomas, Meagan, Lu, Wenyan, Li, Yonghe, Laan, Danuel J., Moyer, Mary P., Russo, Suzanne, Eberhardt, Brian T., Yet, Larry, Keeton, Adam B., Grizzle, William E., Piazza, Gary A.
Publicado em 2014

Design and Synthesis of 4-Heteroaryl 1,2,3,4-Tetrahydroisoquinolines as Triple Reuptake Inhibitors

Por Liu, Shuang, Zha, Congxiang, Nacro, Kassoum, Hu, Min, Cui, Wenge, Yang, Yuh-Lin, Bhatt, Ulhas, Sambandam, Aruna, Isherwood, Matthew, Yet, Larry, Herr, Michael T., Ebeltoft, Sarah, Hassler, Carla, Fleming, Linda, Pechulis, Anthony D., Payen-Fornicola, Anne, Holman, Nicholas, Milanowski, Dennis, Cotterill, Ian, Mozhaev, Vadim, Khmelnitsky, Yuri, Guzzo, Peter R., Sargent, Bruce J., Molino, Bruce F., Olson, Richard, King, Dalton, Lelas, Snjezana, Li, Yu-Wen, Johnson, Kim, Molski, Thaddeus, Orie, Anitra, Ng, Alicia, Haskell, Roy, Clarke, Wendy, Bertekap, Robert, O’Connell, Jonathan, Lodge, Nicholas, Sinz, Michael, Adams, Stephen, Zaczek, Robert, Macor, John E.
Publicado em 2014