Design and Synthesis of 4-Heteroaryl 1,2,3,4-Tetrahydroisoquinolines as Triple Reuptake Inhibitors

[Image: see text] A series of 4-bicyclic heteroaryl 1,2,3,4-tetrahydroisoquinoline inhibitors of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) was discovered. The synthesis and structure–activity relationship (SAR) of these triple reuptake inhibit...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Liu, Shuang, Zha, Congxiang, Nacro, Kassoum, Hu, Min, Cui, Wenge, Yang, Yuh-Lin, Bhatt, Ulhas, Sambandam, Aruna, Isherwood, Matthew, Yet, Larry, Herr, Michael T., Ebeltoft, Sarah, Hassler, Carla, Fleming, Linda, Pechulis, Anthony D., Payen-Fornicola, Anne, Holman, Nicholas, Milanowski, Dennis, Cotterill, Ian, Mozhaev, Vadim, Khmelnitsky, Yuri, Guzzo, Peter R., Sargent, Bruce J., Molino, Bruce F., Olson, Richard, King, Dalton, Lelas, Snjezana, Li, Yu-Wen, Johnson, Kim, Molski, Thaddeus, Orie, Anitra, Ng, Alicia, Haskell, Roy, Clarke, Wendy, Bertekap, Robert, O’Connell, Jonathan, Lodge, Nicholas, Sinz, Michael, Adams, Stephen, Zaczek, Robert, Macor, John E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4094255/
https://ncbi.nlm.nih.gov/pubmed/25050161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500053b
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados