Stabilizing the C(H)2 domain of an Antibody by Engineering in an Enhanced Aromatic Sequon

Monoclonal antibodies (mAbs) exhibiting highly selective binding to a protein target constitute a large and growing proportion of the therapeutics market. Aggregation of mAbs results in the loss of their therapeutic efficacy and can result in deleterious immune responses. The C(H)2 domain comprising...

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Bibliographic Details
Published in:ACS Chem Biol
Main Authors: Chen, Wentao, Kong, Leopold, Connelly, Stephen, Dendle, Julia M., Liu, Yu, Wilson, Ian A., Powers, Evan T., Kelly, Jeffery W.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4852379/
https://ncbi.nlm.nih.gov/pubmed/27128252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b01035
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