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Stabilizing the C(H)2 domain of an Antibody by Engineering in an Enhanced Aromatic Sequon
Monoclonal antibodies (mAbs) exhibiting highly selective binding to a protein target constitute a large and growing proportion of the therapeutics market. Aggregation of mAbs results in the loss of their therapeutic efficacy and can result in deleterious immune responses. The C(H)2 domain comprising...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4852379/ https://ncbi.nlm.nih.gov/pubmed/27128252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b01035 |
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