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Stabilizing the C(H)2 domain of an Antibody by Engineering in an Enhanced Aromatic Sequon
Monoclonal antibodies (mAbs) exhibiting highly selective binding to a protein target constitute a large and growing proportion of the therapeutics market. Aggregation of mAbs results in the loss of their therapeutic efficacy and can result in deleterious immune responses. The C(H)2 domain comprising...
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| 出版年: | ACS Chem Biol |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4852379/ https://ncbi.nlm.nih.gov/pubmed/27128252 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b01035 |
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