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Enhanced aromatic sequons increase oligosaccharyltransferase glycosylation efficiency and glycan homogeneity
N-glycosylation plays an important role in protein folding and function. Previous studies demonstrate that a phenylalanine residue introduced at the n-2 position relative to an Asn-Xxx-Thr/Ser N-glycosylation sequon increases the sequon’s glycan occupancy in insect cells. Here, we show that any arom...
Shranjeno v:
| izdano v: | Chem Biol |
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| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4546532/ https://ncbi.nlm.nih.gov/pubmed/26190824 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.06.017 |
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