Enhanced aromatic sequons increase oligosaccharyltransferase glycosylation efficiency and glycan homogeneity

N-glycosylation plays an important role in protein folding and function. Previous studies demonstrate that a phenylalanine residue introduced at the n-2 position relative to an Asn-Xxx-Thr/Ser N-glycosylation sequon increases the sequon’s glycan occupancy in insect cells. Here, we show that any arom...

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Publicado en:Chem Biol
Main Authors: Murray, Amber N., Chen, Wentao, Antonopoulos, Aristotelis, Hanson, Sarah R., Wiseman, R. Luke, Dell, Anne, Haslam, Stuart M., Powers, David L., Powers, Evan T., Kelly, Jeffery W.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546532/
https://ncbi.nlm.nih.gov/pubmed/26190824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2015.06.017
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