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Rapidly Translated Polypeptides Are Preferred Substrates for Cotranslational Protein Degradation

Nascent polypeptides are degraded by the proteasome concurrently with their synthesis on the ribosome. This process, called cotranslational protein degradation (CTPD), has been observed for years, but the underlying mechanisms remain poorly understood. Equally unclear are the identities of cellular...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Ha, Seung-Wook, Ju, Donghong, Hao, Weilong, Xie, Youming
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4850318/
https://ncbi.nlm.nih.gov/pubmed/26961882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.716175
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