Inhibition of Proteasomal Degradation of Rpn4 Impairs Nonhomologous End-Joining Repair of DNA Double-Strand Breaks

BACKGROUND: The proteasome homeostasis in Saccharomyces cerevisiae is regulated by a negative feedback circuit in which the transcription factor Rpn4 induces the proteasome genes and is rapidly degraded by the assembled proteasome. The integrity of the Rpn4-proteasome feedback loop is critical for c...

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Bibliografiske detaljer
Main Authors: Ju, Donghong, Wang, Xiaogang, Ha, Seung-Wook, Fu, Jiejun, Xie, Youming
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2848573/
https://ncbi.nlm.nih.gov/pubmed/20376190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0009877
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