Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome

The proteasome has pronounced preferences for the amino acid sequence of its substrates at the site where it initiates degradation. Here, we report that modulating these sequences can tune the steady-state abundance of proteins over 2 orders of magnitude in cells. This is the same dynamic range as s...

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Udgivet i:J Biol Chem
Main Authors: Yu, Houqing, Singh Gautam, Amit K., Wilmington, Shameika R., Wylie, Dennis, Martinez-Fonts, Kirby, Kago, Grace, Warburton, Marie, Chavali, Sreenivas, Inobe, Tomonao, Finkelstein, Ilya J., Babu, M. Madan, Matouschek, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2016
Fag:
Protein Synthesis and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938175/
https://ncbi.nlm.nih.gov/pubmed/27226608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.727578
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